|
KMID : 0624620200530020074
|
|
BMB Reports
2020 Volume.53 No. 2 p.74 ~ p.81
|
|
|
Traction Force Microscopy for Understanding Cellular Mechanotransduction
|
|
Hur Sung-Sik
Jeong Ji-Hoon
Ban Myung-Jin
Park Jae-Hong
Yoon Jeong-Kyo
Hwang Yong-Sung
|
|
|
Abstract
|
|
|
|
Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors. Substantial progresses have been made in the field of mechanobiology towards novel methods to understand how cells are able to sense and adapt to these mechanical forces over the years. To address these issues, this review will discuss recent advancements of traction force microscopy (TFM), intracellular force microscopy (IFM), and monolayer stress microscopy (MSM) to measure multiple aspects of cellular forces exerted by cells at cell-ECM and cell-cell junctional intracellular interfaces. We will also highlight how these methods can elucidate the roles of mechanical forces at interfaces of cell-cell/cell-ECM in regulating various cellular functions.
|
|
|
KEYWORD
|
|
|
Focal adhesion, Intracellular force microscopy, Mechanobiology, Monolayer stress microscopy, Traction force microscopy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|